Further, the new INTERSALT research, and therefore recorded an optimistic connection www.datingranking.net/bumble-vs-coffee-meets-bagel/ within urinary Na + /K + proportion and you will blood pressure levels claimed a loss in analytical requirement for brand new correlation in forty two of your 52 locations just after modifications to own covariates along with many years, gender and you can Bmi [thirty-two, 33]
At present there is conflicting evidence regarding the potential blood pressure lowering effects of a reduction in urinary Na + /K + excretion. The TAIM randomized control trial in hypertensive participants on a pharmacological intervention reported no significant difference in DBP between the control diet group and a low Na + /high K + diet group during a six month period . Despite several prior studies reporting an association between blood pressure and the urinary Na + /K + ratio there are several limitations to be considered. conducted in hypertensive participants reported a significant reduction in SBP following 4 weeks of modified low sodium high potassium salt intake compared to participants receiving a normal salt intake , yet all participants were receiving a beta blocker, which is not standard first line treatment for hypertension . In addition, a cross-sectional study, the Dallas heart study, which reported an increase in SBP for an increase in the urinary Na + /K + ratio is limited by the modest correlation the use of single morning urine sample . The PURE study reported a strong linear association between estimated Na + /K + ratio and SBP, that was maintained after covariate adjustment, with the greatest SBP observed with the highest estimated K + and lowest estimated K + excretion . Although we observed that a daily K + excretion of <1 g/day is associated with elevated SBP we observed no association between the urinary Na + /K + excretion ratio and SBP at screening or following DASH-dietary intervention in SS or SR participants. In conjunction with the study by Zanetti et al. , our data suggest high Na + and low K + excretion may increase the likelihood of having increased SBP. However, the lack of association between urinary Na + /K + ratio and SBP in our data do not support a urinary Na + /K + molar excretion ratio of 1:1 as a mechanism to lower blood pressure [16, 17].
The present day data has several characteristics: (1) This new Dash -Sodium demonstration try a very carefully controlled eating studies and you may conformity are continuously monitored, (2) New crossover structure for Na + intervention anticipate participant’s to help you serve as their own handle and you may decreased inter-person variability, (3) 24-h ambulatory hypertension recordings was basically pulled, (4) absence of the latest confounding outcomes of antihypertensive mediations, and (5) 24-h pee sample collection. The major limitation of one’s establish analysis is the relatively modest shot proportions that will have diminished all of our statistical ability to place more compact effects of urinary Na + , K + , and Na + :K + ratio to your SBP. As we failed to to see an instability for the standard services, residual confounding within studies is possible.
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To close out the present day studies of your Dash–Sodium Demonstration reveals that dietary K + supplements is not in the straight down SBP which the new reductions for the SBP observed after the Dashboard slimming down input taken place independently out of an excellent decrease in the brand new urinary Na + /K + removal ratio regardless of the new sodium sensitiveness from blood pressure. The data don’t secure the place out-of a 1:1 molar excretion proportion regarding Na + /K + as the blood pressure level lowering strategy in the Us Ebony and you may non-African People in the us and you may keep the DRI recommendation to not suggest day-after-day K + consumption advice. Because of the restrictions of your current data therefore the ongoing debate regarding your character out-of losing weight K + towards the blood pressure future cautiously regulated scientific studies are required to clarify the possibility perception off diet K + and urinary Na + /K + excretion proportion on blood circulation pressure in both hypertensive and you will normotensive SS and you can SR people.